Genes can be controlled by hydrogen peroxide


06/08/2012

Hydrogen peroxide does not exist only in the form are sold in pharmacies aqueous solution. Human cells also produce and use for their own needs, this reagent. But scientists from the University of North. Caroline learned how to use hydrogen peroxide to drive the expression of genes within the cell. In addition, the technique proposed by researchers can be used as a highly sensitive detector peroxide, allowing researchers to determine the role played by this molecule in cell life.

In a normally functioning healthy cell, hydrogen peroxide is used to send messages: This reagent carries signals through space within the cell, enabling it to respond appropriately to external stimuli. Immediately after transmitting the hydrogen peroxide is scattered and lost. The researchers note that the molecules of hydrogen peroxide are ideal carriers of signals, since they are small and quick in movement and disappearance, which is also very important, as there are no problems with their accumulation in the cell. Messaging provides hydrogen peroxide by oxidation of certain amino acids within the protein, causing a change in its functionality.

A team of researchers led by Alex Deiters decided to check whether you can do something with the oxidative capacity of the substance to be able to control the expression of genes within the cell. In the experiment, the scientists Cycled gene by which the beetles, firefighters lit. They created a molecule sensitive to hydrogen peroxide and activating luciferase expression in cells beetle. Scientists have witnessed in the presence of molecular hydrogen peroxide proceeded synthetic gene expression in the cells, causing them to light up.

Researchers note that this method can be used not only for detection of hydrogen peroxide in the cells, but also for the expression of any gene in response to the presence of peroxide. Moreover, the sensitivity of the resulting system for peroxide is far superior to all previous results.

According to the materials Sciencemagis.ru


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