Intranasal delivery of the construction of bacterial protein flagellin (flagellin) in the human body by grafting may activate innate immunity and protect against signs of acute pneumonia, so say researchers from France, based on the results of recent studies. The results of the study were published in the October issue of the journal Infection and Immunity (Infection and Immunity) in 2010.
Streptococcus pneumonia (Streptococcus pneumoniae) is the primary cause of respiratory infections in infants and elderly people throughout the world. Many people are unaware of even carriers of bacteria in their throat, but because the current of innate immunity not experience severe symptoms, however, lack the immune response in the infected individuals may lead to pneumococcal pneumonia requiring complex invasive treatments.
To determine the ability of flagellin to protect the body from pneumonia, the researchers used laboratory methods intranasal inoculation of two groups of mice infected with streptococcal infection. Flagellin used in the treatment of one group of animals. As a result, the survival rate of mice treated with flagellin ranged between 75 and 100%, whereas the mice that were not treated, died within 3-4 days. Furthermore, in the body infected mice receiving flagellin was observed a significant reduction of bacteria in the lungs after only 24 hours and complete clearance of them within 2 days.
In addition, researchers evaluated the therapeutic importance of treatment flagellin infecting two groups of mice with Streptococcus pneumoniae and then injected flagellin itranazalnym by the body of only one of the animals after 24 hours. Levels of protection in mice exposed to flagellin. of 60-100%, while all mice that were treated died.
"Our results showed that local stimulation of the sole and well-characterized molecule, specifically flagellin, is sufficient to increase the innate immune defense of the lungs and controlling pneumococcal pneumonia, highlighting the advantages of the use of molecular microbial samples as a basis for the development of antimicrobial therapy" - the researchers reported news site.