Harvard scientists have developed a new biometric method of delivery in a partially occluded vessels nanoterapevticheskih means that dissolve clots are formed before they have time to cause death or serious violations.
To dissolve blood clots on the new technology need only a small dose of the drug, commonly used for this purpose, to minimize side effects (bleeding). The results of the experts at Harvard are very important for the treatment of strokes, heart attacks, pulmonary embolism, in general, all that can lead to sudden death.
The idea researchers assembled in platelet adhering to the walls quickly narrow blood vessels, making thus its contribution to the formation of atherosclerotic plaques. Scientists believe that the circulating platelets from sticking to the walls of narrow vessels and contributes to the high voltage in them when moving blood.
Nanoscale means Harvard scientists developed to combat thrombus has approximately the same dimensions as platelets, and includes biodegradable nanoparticles coated drug substance dissolving clots. This drug is a tissue plasminogen activator (abbreviated tPA). Like a lump of wet sand, which decays into individual grains of sand in his riding in the hands of, the aggregates dissociate in the blood vessels with high shear stress provoked by their partial occlusion of atherosclerotic plaque, highlighting the individual particles with tPA. The latter, in turn, communicate with formed thrombus and dissolved.
Thrombosis disrupts the normal circulation of blood towards the lungs, the heart, the brain, which in developing countries is one of the most common causes of disability and death. Now for the treatment of patients with stroke, heart attack, pulmonary embolism, and other types of thrombosis mainly use tromborastvoryayuschie potent drugs. However, these substances are freely circulating throughout the body in high concentrations, may cause dangerous and sometimes even fatal bleeding.
Unlike these drugs nanoterapevticheskoe new drug has no such side effects. The results of experiments on mice have shown that enough of the fiftieth part of a therapeutic dose of medication that a much reduced risk of complications.
According to the materials Sciencemagis.ru