Brazilian spider bite causes not only unbearable pain to the person, insect venom causes a strong erection in men, which can last for several hours. Recently, scientists were able to identify a representative of the spider venom that same chemical that stimulates erections.
In Brazil, emergency medical personnel can immediately identify the victims affected by the bite of the Brazilian wandering spider (Phoneutria nigriventer). Patients were characterized not only severe pain and high blood pressure as well as the involuntary erection, which gives discomfort to the patient.
"Erection - a side effect of which is shown, along with the pain any man bitten by a spider of this species," - said the head of research RAMOUL Leyte (Romulo Leite) from the Medical College of Georgia. "We hope that the identification of the substance, eventually, lead to the development of drugs for the treatment of erectile dysfunction."
The study was presented at the annual meeting of the American Physiological Society (APS).
A recent analysis conducted by researchers at Johns Hopkins University, has shown that about 18 million men in the United States suffer from erectile dysfunction. Also, the survey found that one in three men with mild to moderate form of erectile dysfunction did not help Viagra, others have successfully used the same drugs like Levitra or Cialis. And for men with severe erectile dysfunction use of these drugs has been altogether successful.
A group of researchers from the Medical College of Georgia, headed by RAMOUL Leyte identified various components of spider venom, then test them on rats to find the one that causes an erection. Component duplicated as Tx2-6, was relatively short chain of amino acids called a peptide.
Researchers chemical injected into the rats, thus stimulating an erection. A small device like a needle was inserted into each of the male sexual organ to measure the change in pressure, which is observed by increasing the blood flow in the blood vessels of the penis. As a result, rodents, which injected venom showed significant increase in body size in comparison with a control group of rats.
Scientists have also found an increase in nitric oxide levels in the two main cylindrical cavities that regulate the length of the penis and are Latin name corpora cavernosa.
The value of nitric oxide is clear when one considers the whole process of sexual arousal and the onset of erection: The brain senses sexual arousal in the body and certain neurons begin to produce nitric oxide, which signals the beginning of an erection. There is a few biochemical steps, one of which involves the production of an enzyme duplicated as cGMP. This enzyme causes a weakening of the muscles of the two cylinders of the penis, so that blood filled the extended tube. (In the excited state in the male penis can contain about 10 times more blood than in the state of rest.)
But the erection is known to not last forever. A substance called PDE-5 enzyme cGMP is terminated and the penis takes its normal state.
The action of the most popular drugs for erectile dysfunction - Viagra, Cialis, and Levtra - is blocking agents PDE-5.
Chemicals found in the venom of the Brazilian spider acts otherwise, affecting the duration of the state of erection. Toxin somehow increase the amount of nitric oxide, which plays an important role in the erection. Scientists suggest that the combination of a synthetic version of the spider venom with a drug like Viagra to cause a striking effect.
"The combination of the two drugs could be more effective for patients with erectile dysfunction who showed a mild reaction to Viagra", - noted in the conclusion RAMOUL Leyte.
Original: Livescience.com Translation: M. Potter