Low levels of vitamin D in the body - the cause of longevity


06/11/2012

Dutch researchers have found that the cause of hereditary longevity is a low level of vitamin D in the body, as well as changes in a particular gene. The research work has been published in the Canadian Medical Association Journal.

In the study, experts have studied the data of 380 European families who attended at least two relatives of the long-lived age of about 90 years. The study included the participation of brothers and sisters with their children and partners of the latter. 1,038 thousands of children have been studied, while 460 people were in the control group. Participation partners children centenarians experiment was permitted, because they had similar age and were exposed to the same environmental conditions which could potentially change the body of vitamin D.

By measuring the 25 levels of vitamin D, the researchers divided them into categories based on different months of the year when they will vary depending on the season. Solarium volunteers were divided into the following categories: never, once a year and six or more times a year. The study also took into account all the factors affecting the level of vitamin D: gender, age, body mass index, time of year, the consumption of vitamins, as well as the kidneys. Moreover, three genes was examined the influence of genetic variation responsible for the levels of vitamin D.

"We found that the offspring of centenarians who have had at least one 90-year-old brother or sister, was marked by a low level of vitamin D in comparison with the control group, even though the possible side factors and single nucleotide polymorphism, which is associated with the levels of of the vitamin, "- said the authors of the study from the Canadian Medical Association, the word under the direction of Dr. Diana Van Hemst of Leiden University Medical Center.

She added that in the offspring of centenarians variation in the gene CYP2R1 also rarely met. It is associated primarily with susceptibility of the organism to accumulate large amounts of vitamin D.

Meanwhile, in earlier studies, it was suggested that low levels of vitamin D is closely linked with high mortality rates, the development of cardiovascular disease, certain types of cancer, allergies and disorders of intelligence. But the authors of this study believe that this is evidence of a direct cause-and-effect relationship, and a number of additional research is needed to fully understand the relationship that is present between longevity and levels of vitamin D in the body.


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