Admission sedative can cause pneumonia


07/12/2012

A common medication sedation is usually prescribed by the doctor, can increase the risk of pneumonia by 50%, and even lead to death. This was reported by the Institute of Cognitive Neuroscience at University College London.

Benzodiazepines have a wide spectrum of action. Doctors prescribe them to patients, usually in cases of anxiety and restlessness, insomnia, epilepsy and muscle spasms. They are often prescribed to people as palliative care, as the drugs improve the quality of life of the patient, which is not long to live, and as a sedative, as it reduces the emotional stress and calms without soporific effect.

Acceptance of these drugs may increase the risk of infection and death due to sepsis in patients whose condition is marked as extremely critical. The study authors decided to test whether they can trigger the development of fatal pneumonia.

Having analyzed the medical data of patients using the database Health Improvement Network, they stopped their attention to the 5000 patients diagnosed with pneumonia between 2001 and 2002god, as well as obtaining detailed information on the health status of the control group of volunteers - 29,500 people who have this disease is not mentioned . Scientists particularly interested in receiving participants from both groups of funds benzodiazepine. The results showed that when regulyarnyom taking drugs such as diazepam, lorazepam and temazepam (the exception was chlordiazepoxide), the risk of pneumonia increased by 54%. In this case, the experts took into account the presence of infection in the past, smoking status, and other comorbidities.

A further study found that those taking benzodiazepines were exposed to the risk of death within 30 days after the disease pneumonia by 22% and 32% over the next three years. The researchers caution that their findings have not yet definitively confirm the cause-and-effect relationship, but they suggest that the discovery could be the basis for further research, as it intersected with clinical trials conducted earlier doses of benzodiazepines.

"Benzodiazepines - is common drugs with significant immune effect. Given their widespread use, it is required to hold a series of further studies to accurately assess their safety in the context of infection," - concluded the authors.

The study was published in the journal Thorax.


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