"Memory molecule" is not related to its formation


03/01/2013

Studies in transgenic mice, conducted independently by neuroscientists have shown that protein kinase M zeta (PKM-?), another protein known as the "memory molecule", in reality, nothing to do with its formation and maintenance. Summary of the two publications that appeared in the journal Nature, reports Nature News.

Presentation of scientists about "memory molecule" was based on experiments in which they were able to erase the memories of rats by blocking with a special peptide inhibitor ZIP for a while work PKM-?. The introduction of this peptide in different areas of the brain, which was completed just before the stimulus-a reminder, led to the fact that the previously elaborated conditioned reflexes disappear in animals.

The authors of two new articles have turned their attention that all scientific publications, which investigated the role of PKM-?, were conducted using exactly inhibitor ZIP. Then the researchers decided to reproduce this effect by removing the gene itself PKM-? of the genome of animals, without the help of the peptide.

As it turned out, the removal of "gene memory" in transgenic mice did not influence the memorization of them new information. This effect could be explained by a kind of compensation - acting as the PKM-? in the development of some other protein. However, a similar lack of effect on memory was observed and in those mice in which the gene was deleted from the genome as adults when full payment is nearly impossible.

It is noteworthy that the inhibitor on the ZIP memory of transgenic mice and control animals have the same effect. Thus it creates the effect of erasing the memory was not associated with inhibition of PKM-?, as previously assumed, and the action to some as yet unknown target.

In neuroscience one of the fastest growing areas is the study of memory. Memory is the basis of long-term potentiation - increasing the efficiency of the pulse in certain synapses between neurons. It should be noted that previously it was believed that the increase in synaptic efficacy depends precisely on the PKM-?.


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