Scientists: obesity gene is associated with skin cancer


05/03/2013

Associated with obesity gene FTO may lead to the development of melanoma - skin cancer. This was reported by the researchers of the University of Leeds in the UK, reports Medical Xpress.

People with a particular variation of the FTO-gene (intron 8) in the segment of DNA, the study found, are more at risk of developing melanoma than the rest. Previously, in other variations of the gene FTO-(intron 1) were recognized by scientists important genetic risk indicator of obesity.

These variations are related to body mass index (BMI). Raised BMI promotes various human diseases, including diabetes mellitus type 2, as well as kidney and uterus. However, a recent study has shown a link of the FTO gene with the occurrence of melanoma, which is not associated with obesity. It was found that the FTO gene plays a more important role than previously expected (he was involved in a number of different diseases with different sites).

"We have identified the main link obesity gene in melanoma. And we have a following question: Will proven in further studies of gene linkage with other diseases? Trying to understand the behavior of the gene FTO, researchers have previously studied its effects exclusively on metabolism and appetite. Now it is obvious that we know very little about the role of this gene, "- says Dr. Mark Iles, author of.

Experts have examined in the study of more than 13,000 samples of tumor patients with melanoma and 60,000 healthy people.

In Britain, melanoma is the fifth most common place it is fixed every year about 12,800 new cases and 2,200 deaths.

"The authors’ conclusions are very interesting, if they are true, then we can talk about the possibility of the development of effective drugs for the treatment of melanoma. New information about the molecular mechanisms leading to the development of skin cancer, has allowed us to create a number of new drugs to fight cancer of the skin that can have real value for patients. Nevertheless, this does not negate the need for precautions on tan - from a long stay on the beach it would be better to give up. triple the risk of developing melanoma can excessive UV irradiation only once in two years, "- said Dr. Julie Sharp from the fund Cancer Research UK.

Scientists have published a study in the journal Nature Genetics.


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