Cells were taken from the gingival tissues of adults may be combined with the cells molars mouse embryos to form roots of teeth. This result was achieved in a study published in the Journal of Dental Research. This method is still a long way for the practical implementation, but it was an important step on the road to bioengineered replacement of lost teeth.
Teeth grow when the embryonic epithelial cells in the mouth combined with mesenchyme from the neural crest. Previous studies have demonstrated that these cells can be combined in a laboratory for the formation of the teeth, but the scientists were challenged to find neembrionalny source of these cells.
The source of these cells, a team of Cell Biology Paula Sharpe learned the epithelial cells of the gums adults cultivated in the laboratory, and added dental mesenchymal cells from mouse embryos. A week later, the mixture was transplanted researchers in protecting kidney tissue in live mice, where some of the cells developed into hybrid human teeth and mouse to dentin, enamel and roots.
Sharpe said: "The next important step will be to find ways to use adult mesenchymal cells, because at the moment we can only use embryonic mesenchymal cells."