The research team at the California Institute of San Diego has created a ’nanosponges’ which are capable of removing a wide class of toxins from the blood, including the bee and snake venoms, and even Methicillin-resistant Staphylococcus aureus (MRS).
These nanosponges, which test is conducted only until the mouse, capable of neutralizing the pore-forming toxins that kill cells by forming holes in the cell membranes. Unlike other antivenoms to be synthesized individually for each type of toxin nanosponges are able to absorb a wide range of toxins, regardless of their molecular structure.
In a study published in the journal Nature Nanotechnology, 89% of mice in which were previously entered nanosponges, survived a lethal dose of toxin MRS. Nanogubok after the introduction of a lethal dose saved the lives of 44% of the mice.
"It’s a new way to remove toxins from the blood," - said Professor Liangfang Zhang, lead author of the study.
"Instead of creating a medication for each individual toxin, we have developed a platform that allows you to neutralize the toxins formed by a wide range of pathogens, including IFAs and other bacteria that are resistant to antibiotics."
Now, the team switched to the practical implementation of the fruits of their research.
"One of the first applications is the development of medicines for antivirulentnyh MRS. For this reason, we have studied one of the most poisonous toxins MPC in the course of our experiments," - said Dr. Che-Ming Hu, one of the study participants.