Amphibians can help in the fight against drug-resistant bacteria


24/01/2008

Italian researchers have found that a natural agent present in the skin of a frog in a position to suppress drug-resistant strains of bacteria that cause hospital-acquired (nosocomial) infections.

Resistant strains of bacteria to traditional therapies in recent years more and more concerned about scientific minds. Bacteria adapt to any type of antibiotics, which negates all the efforts to combat the infection and can lead to complete failure of antibiotic exposure to infection.

However, scientists have a new effective weapon to combat harmful bacteria - antimicrobial peptides. In addition, it was found that the richest "deposit" of such peptides is the skin of amphibians, especially frogs and toads.

Background: Antimicrobial peptides (antimicrobial peptides) - very short protein molecules consisting of about 20-30 amino acids that are produced by cells of animals and humans to fight germs. Antimicrobial peptides - part of the innate immunity. Unlike antibodies, they are not modified during the lifetime of an organism and does not "adjusted" to new types of pathogens.

Nosocomial infections are associated with a variety of drug-resistant strains of bacteria are the main causes of secondary diseases.

In their studies, the scientists tested the five antimicrobial peptides (temporin A, B and G, esculentin 1b and bombinin H2), taken from the skin of three different species of frogs and toads (Rana temporaria, Rana esculenta and Bombina variegata). We investigated the ability of peptides to resist strains of bacteria that cause hospital-acquired human disease.

Initial results showed that all peptides are effective antibacterial agents. Further investigation found that temporin A, B and G are more effective against gram-positive bacteria, esculentin 1b began to act in some time (from 2 to 20 minutes) and bombinin H2 acted similarly in all kinds of strains of bacteria.

The researchers expressed the hope that these peptides undoubtedly will contribute to the development of new anti-infective drugs of high efficiency, which will help relieve medical institutions of nosocomial infections. Just for you the most interesting news on the pages of our portal.

Original: Sciencedaily.com


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